🗺 ABCT 101 · Course Map Modern Approaches in Biopharmaceutical Development
Seven lecture pages — L1–L6 plus L8 Structural Biology — then a three-lecture Immunology series, all on one structure. Each page: Master Logic → numbered topics (one-line takeaway + expandable details) → Exam Focus. The midterm covers L1–L6. An Immunology series (IMM-L1–L3) follows.
六講、一套骨架。每頁：Master Logic → 編號主題（一句要點＋可展開細節）→ 考點。期中考覆蓋 L1–L6；其後另設 免疫學系列（IMM-L1–L3）。
101 · L1 Introduction to Biologics
生物藥＝用活細胞造藥，製程即產品；歷史由「執藥材」走到「開工廠」。Biologics are made by living cells — the process is the product.
101 · L2 Proteins, Antibodies & Related Biologics
蛋白與抗體是主力；ADC 是「抗體＝地址、linker＝時程、毒藥＝炸藥」。Proteins and antibodies do the work; an ADC is an address + timer + warhead.
101 · L3 Nucleic Acid, Carbohydrate & Drug Delivery
核酸與醣類生物藥成敗在遞送：地址（靶向）＋時程（控釋）。For nucleic-acid drugs, value accumulates in the delivery system, not the sequence.
101 · L4 Genomics & Bioinformatics
基因組學三問——讀、懂、改；每個工具都屬其中一問。Three questions: read, understand, edit.
101 · L5 Transcriptomics
同一個基因組，不同的演奏；定量的關鍵在「先除長度還是先除深度」。Same genome, different performance — normalisation is about which correction comes first.
101 · L6 Proteomics & Multi-omics
基因組是零件清單，蛋白質才是機器；DDA 是採訪最紅明星，DIA 是全程監控。The genome is a parts list; proteins are the machines.
101 · L8 Structural Biology Part I
四種「看見看不到的東西」的方法：晶體、電子、磁核、散射的 X 光。結構不是照片，而是模型＋驗證統計。
Four ways to see the invisible — and the trade-off between material, resolution and dynamics.
🧠 Immunology — a second series · 免疫學部分
教授自訂編號，與生物藥 L1–L8 撞號，故另立 IMM 區塊。三講：基本概念 · 先天與適應性 · 補體、MHC、疫苗與過敏。
The lecturer numbered these separately from the biologics lectures, so they sit in their own IMM block: basic concepts · innate & adaptive · complement, MHC, vaccines and hypersensitivity.
IMM-L1 Basic concept of Immunology
三道防線、兩大免疫系統、一個辨識機制（PAMP／DAMP／PRR）。考點是那三個 pH 數字與 TLR 對應。Three lines of defence, two systems, and one recognition mechanism.
IMM-L2 Innate & Adaptive Immunity
把免疫學拆回零件：PAMP／PRR／DAMP 辨識 → 白血球執行 → 抗體與 T 細胞 → 補體級聯 → MHC 呈遞。考點是五類 isotype、C3／C5 convertase、MHC I vs II 的肽段長度與共受體。
IMM-L3 Complement, MHC, Vaccines & Hypersensitivity
補體三路徑 → MAC 與調控 → MHC I／II → 抗原處理 → B／T 細胞活化 → V(D)J → 細胞因子 → 免疫原性 → 疫苗七類 → 四型過敏。